251680 Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem

251680
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₉N₄O₅ · Na 14663-23-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      251680-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewA cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.
          Catalogue Number251680
          Brand Family Calbiochem®
          References
          ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
          O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
          Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
          Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
          Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
          Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
          Product Information
          CAS number14663-23-1
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₁₄H₉N₄O₅ · Na
          Chemical formulaC₁₄H₉N₄O₅ · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRyanodine receptor
          Purity≥ 95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMU3875000
          Safety Information
          R PhraseR: 20/21/22-45

          Harmful by inhalation, in contact with skin and if swallowed.
          May cause cancer.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          251680

          References

          Reference overview
          Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
          O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
          Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
          Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
          Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
          Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-June-2009 RFH
          DescriptionA skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.
          FormOrange solid
          CAS number14663-23-1
          RTECSMU3875000
          Chemical formulaC₁₄H₉N₄O₅ · Na
          Structure formulaStructure formula
          Purity≥ 95% by HPLC
          SolubilityAqueous alkaline solutions or DMSO (3 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 2816
          ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
          O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
          Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
          Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
          Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
          Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.