251600 | Daidzein - CAS 486-66-8 - Calbiochem

251600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₄ 486-66-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      251600-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewInactive analog of Genistein (Cat. No. 345834). Blocks the G1 phase of the cell cycle in Swiss/3T3 cells by inhibiting casein kinase II activity. Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC50= 45 µM and 75 µM, respectively).
          Catalogue Number251600
          Brand Family Calbiochem®
          Synonyms4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
          References
          ReferencesGuo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
          Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
          Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Product Information
          CAS number486-66-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₅H₁₀O₄
          Chemical formulaC₁₅H₁₀O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMiaPaC-2, PANC-1
          Primary Target IC<sub>50</sub>45 µM, 75 µM for inhibiting the growth of MiaPaC-2 and PANC-1 cells, respectively
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDJ3100040
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 24-26

          Avoid contact with skin.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          251600

          References

          Reference overview
          Guo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
          Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
          Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2008 RFH
          Synonyms4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
          DescriptionInactive analog of genistein (Cat. No. 345834). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Inhibits epidermal growth factor (EGF) receptor autophosphorylation (IC50 >300 µM). Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC50= 45 µM and 75 µM, respectively).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number486-66-8
          RTECSDJ3100040
          Chemical formulaC₁₅H₁₀O₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 2801
          ReferencesGuo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
          Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
          Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.