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14-435M | DYRK1A Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-435) and in bulk (cat# 14-435-K).
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      Replacement Information
      Catalogue Number14-435M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionDYRK1A Protein, active, 250 µg
      OverviewRecombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag
      Product Information
      ApplicationActive, recombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
      Gene Symbol
      • DYRK1A
      • HP86
      • DYRK
      • DYRK1
      • MNBH
      • hMNB
      • MNB
      Protein TargetDYRK1A
      Purification MethodGSH-agarose chromatography
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13627 # May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
      SIZE: 763 amino acids; 85584 Da
      SUBUNIT: Interacts with RANBP9.
      SUBCELLULAR LOCATION: Nucleus speckle.
      TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
      DEVELOPMENTAL STAGE: Expressed in the developing central nervous system.
      PTM: Autophosphorylated on tyrosine residues.
      DISEASE:SwissProt: Q13627 # Overexpressed 1.5-fold in fetal Down syndrome brain.
      SIMILARITY: SwissProt: Q13627 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight90kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of 50mM Woodtide substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-435) and in bulk (cat# 14-435-K).
      Transport Information
      Supplemental Information

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-435 DYRK1A Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases