323115 | DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem

323115
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₈BrNO₃ 101860-83-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      323115-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
          Catalogue Number323115
          Brand Family Calbiochem®
          Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
          References
          ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.
          Product Information
          CAS number101860-83-7
          FormOff-white solid
          Hill FormulaC₉H₈BrNO₃
          Chemical formulaC₉H₈BrNO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          323115

          References

          Reference overview
          Lally, B.E., et al. 2007. Cancer Res. 67, 8791.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-August-2011 JSW
          Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
          DescriptionA cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number101860-83-7
          Chemical formulaC₉H₈BrNO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.