260930 DNA Polymerase Sliding Clamp Inhibitor, RU7

260930
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₁Br₂NO₅S₂ 355400-87-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      260930-10MG
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          Plastic ampoule 10 mg
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          Description
          Overview

          This product has been discontinued.





          A 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II and IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
          Catalogue Number260930
          Brand Family Calbiochem®
          SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
          References
          ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
          Product Information
          CAS number355400-87-2
          FormYellow solid
          Hill FormulaC₁₄H₁₁Br₂NO₅S₂
          Chemical formulaC₁₄H₁₁Br₂NO₅S₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          DNA Polymerase Sliding Clamp Inhibitor, RU7 SDS

          Title

          Safety Data Sheet (SDS) 

          DNA Polymerase Sliding Clamp Inhibitor, RU7 Certificates of Analysis

          TitleLot Number
          260930

          References

          Reference overview
          Georgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
          DescriptionA 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II & IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number355400-87-2
          Chemical formulaC₁₄H₁₁Br₂NO₅S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.