262015 | DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

262015
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₆N₂O₄ 6960-45-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      262015-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
          Catalogue Number262015
          Brand Family Calbiochem®
          Synonyms7-Nitroindole-2-carboxylic acid, CRT0044876
          References
          ReferencesMadhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.
          Product Information
          CAS number6960-45-8
          ATP CompetitiveN
          FormTan solid
          Hill FormulaC₉H₆N₂O₄
          Chemical formulaC₉H₆N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAPE 1
          Primary Target IC<sub>50</sub>~3 µM against APE1 (human apurinic/apyrimidinic endonuclease
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          262015

          References

          Reference overview
          Madhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-August-2018 JSW
          Synonyms7-Nitroindole-2-carboxylic acid, CRT0044876
          DescriptionA cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number6960-45-8
          Chemical formulaC₉H₆N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesMadhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.