574215 D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

574215
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₁₁NOS₂ 4478-93-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574215-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
          Catalogue Number574215
          Brand Family Calbiochem®
          Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
          References
          ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
          Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
          Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
          Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
          Maheo, K., et al. 1997. Cancer Res. 57, 3649.
          Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
          Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
          Product Information
          CAS number4478-93-7
          ATP CompetitiveN
          FormSlight yellow liquid
          Hill FormulaC₆H₁₁NOS₂
          Chemical formulaC₆H₁₁NOS₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationD,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
          Biological Information
          Primary TargetPotent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
          Purity≥98% by UPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          574215

          References

          Reference overview
          Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
          Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
          Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
          Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
          Maheo, K., et al. 1997. Cancer Res. 57, 3649.
          Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
          Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-March-2008 JSW
          Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
          DescriptionAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.
          FormSlight yellow liquid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number4478-93-7
          Chemical formulaC₆H₁₁NOS₂
          Structure formulaStructure formula
          Purity≥98% by UPLC
          SolubilityDMSO (20 mg/ml) or ethanol (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
          Toxicity Standard Handling
          ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
          Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
          Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
          Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
          Maheo, K., et al. 1997. Cancer Res. 57, 3649.
          Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
          Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.