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GF170 | DKK-1 Protein, Human Recombinant

10 µg  
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      Replacement Information

      Key Specifications Table

      HEK293 Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
      Catalogue NumberGF170
      DescriptionDKK-1 Protein, Human Recombinant
      Alternate Names
      • Dickkopf related protein 1
      • DKK1
      • DKK
      • SK
      Background InformationDickkopf related protein 1 (Dkk1) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4, and a related protein, Soggy. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      ApplicationThe Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
      SourceHEK293 Cells
      Cross ReactivityNone
      UniProt Number
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Recombinant Human -2573001 2573001
      Recombinant Human -2604334 2604334
      Recombinant Human DKK-1 2458038
      Recombinant Human DKK-1 - 2039816 2039816
      Recombinant Human DKK-1 - 2092740 2092740
      Recombinant Human DKK-1 - 2219399 2219399
      Recombinant Human DKK-1 - 2314807 2314807
      Recombinant Human DKK-1 - Q2007176 Q2007176
      Recombinant Human DKK-1 -2500703 2500703
      Recombinant Human DKK-1 -2702159 2702159
      Recombinant Human DKK-1 -2705930 2705930


      New Products: Volume 3, 2012

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      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors