309795 | DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem

309795
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₈N₂O₆S₄ · 2Na 53005-05-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      309795-250MG
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          Plastic ampoule 250 mg
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          Description
          OverviewBinds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl uptake (IC50 = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.
          Catalogue Number309795
          Brand Family Calbiochem®
          Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
          References
          ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
          Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
          Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
          Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
          Product Information
          CAS number53005-05-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₈N₂O₆S₄ · 2Na
          Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCl- uptake
          Primary Target IC<sub>50</sub>150 nM inhibiting Cl- uptake in neuroblastoma cells
          Purity≥85% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          309795

          References

          Reference overview
          Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
          Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
          Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
          Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.

          Brochure

          Title
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
          DescriptionBinds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
          FormYellow solid
          CAS number53005-05-3
          Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
          Structure formulaStructure formula
          Purity≥85% by TLC
          SolubilityH₂O (0.5%)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Irritant
          ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
          Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
          Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
          Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.