252801 | DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

252801
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₄N₂O₄ 959122-11-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      252801-5MG
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          5 mg
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          Description
          OverviewAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
          Catalogue Number252801
          Brand Family Calbiochem®
          References
          ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
          Product Information
          CAS number959122-11-3
          FormLight yellow solid
          Hill FormulaC₂₆H₂₄N₂O₄
          Chemical formulaC₂₆H₂₄N₂O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          252801

          References

          Reference overview
          King, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-December-2015 JSW
          DescriptionAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 µM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 µM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
          FormLight yellow solid
          CAS number959122-11-3
          Chemical formulaC₂₆H₂₄N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.