407141 D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem

407141
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₆H₅₇O₃₀P₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407141-1SET
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          Plastic ampoule 1 set
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          Description
          OverviewA cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3].
          Note: Each set contains 1 µmol Bt3(1,3,5)IP3/AM and 10 mg PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.
          Catalogue Number407141
          Brand Family Calbiochem®
          SynonymsBt₃(1,3,5)IP₃/AM
          References
          ReferencesRudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.
          Product Information
          ATP CompetitiveN
          FormClear syrup
          Formulation1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC® F-127 detergent.
          Hill FormulaC₃₆H₅₇O₃₀P₃
          Chemical formulaC₃₆H₅₇O₃₀P₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationD-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl- is a cell-permeable derivative of Ins(1,3,5)P3.
          Biological Information
          Primary TargetA cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3]
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407141

          References

          Reference overview
          Rudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-February-2008 JSW
          SynonymsBt₃(1,3,5)IP₃/AM
          DescriptionNovel analogs capable of exhibiting Ins(1,4,5)P3-like agonist or antagonist effects on calcium release are more resistant to hydrolysis and metabolic degradation than IP3 or IP4. Consequently, they can produce a prolonged activation of cellular processes dependent on the Ins(1,4,5)P3 receptor interaction. These tools are important in the elucidation of the molecular interactions of Ins(1,4,5)P3 with its intracellular receptor and with Ins(1,4,5)P3-kinase and 5-phosphatase. Acetoxymethyl esters of inositol phosphate are highly lipophilic. Hence, they easily diffuse through the cell membrane. Note: Each set contains 1 µmol of Bt3(1,3,5)IP3/AM and 10 mg of PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.
          FormClear syrup
          Formulation1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC® F-127 detergent.
          Intert gas (Yes/No) Packaged under inert gas
          Recommended reaction conditions
          Protocol for Treating Cells with IPx 1. Add 10 µl DMSO to 1 µmol Bt3(1,3,5)IP3/AM to make a 100 mM stock solution. 2. Prepare a 10% PLURONIC® F-127 solution in DMSO. DO NOT FREEZE! 3. Obtain 1 ml uniform cell suspension and place 500 µl of the suspension in a test tube. 4. Add 1 µl of the DMSO/Bt3(1,3,5)IP3/AM solution (step 1) and 2 µl of the 10% PLURONIC®/DMSO stock solution (step 2) to the cell suspension in step 3 and mix. 5. Add the cells/Bt3(1,3,5)IP3/AM /PLURONIC® mixture from step 4 to a tube containing the remaining 500 µl cell suspension. Mix carefully. The total test-tube volume now equals 1 ml.
          Chemical formulaC₃₆H₅₇O₃₀P₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (IPx, 100 mM; PLURONIC® F-127 detergent, 100 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!
          Toxicity Standard Handling
          ReferencesRudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.