110145 D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

110145
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₉NO₃ 3102-57-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      110145-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
          Catalogue Number110145
          Brand Family Calbiochem®
          SynonymsC₂ Ceramide
          References
          ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
          Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
          Obeid, L.M., et al. 1993. Science 259, 1769.
          Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
          Product Information
          CAS number3102-57-6
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₉NO₃
          Chemical formulaC₂₀H₃₉NO₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibits cell growth and induces apoptosis in HL-60 cells
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          110145

          References

          Reference overview
          Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
          Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
          Obeid, L.M., et al. 1993. Science 259, 1769.
          Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

          Brochure

          Title
          Bioactive Lipids Technical Bulletin
          MAP Kinases Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsC₂ Ceramide
          DescriptionBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells.
          FormWhite to off-white solid
          CAS number3102-57-6
          Chemical formulaC₂₀H₃₉NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (25 mg/ml), Ethanol (5 mg/ml) or Methanol (5 mg/ml). When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
          Toxicity Irritant
          ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
          Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
          Obeid, L.M., et al. 1993. Science 259, 1769.
          Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.