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454863 | D-erythro-MAPP - CAS 143492-38-0 - Calbiochem

454863
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₃₉NO₂ 143492-38-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      454863-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramidase versus IC50 > 500 µM for acid ceramidase). This inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breakdown of ceramide to sphingosine.
          Catalogue Number454863
          Brand Family Calbiochem®
          Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
          References
          ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
          Hannun, Y.A. 1996. Science 274, 1855.
          Product Information
          CAS number143492-38-0
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₂₃H₃₉NO₂
          Chemical formulaC₂₃H₃₉NO₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetAlkaline ceramidase
          Primary Target IC<sub>50</sub>1-5 µM for alkaline ceramidase versus > 500 µM for acid ceramidase
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          454863

          References

          Reference overview
          Bielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
          Hannun, Y.A. 1996. Science 274, 1855.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-November-2014 JSW
          Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
          DescriptionA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceraminidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramides versus IC50 >500 µM for acid ceraminidase). This inhibition results in and over 3-fold increase in endogenous ceramide in treated cells due to a lack of breakdown of ceramide to sphingosine.
          FormSolid
          CAS number143492-38-0
          Chemical formulaC₂₃H₃₉NO₂
          Structure formula
          Purity≥98% by NMR
          SolubilityEthanol (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
          Hannun, Y.A. 1996. Science 274, 1855.