239805 | Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem

239805
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₀N₂O₃ 18172-33-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239805-5MG
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          Alu drum 5 mg
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          Description
          OverviewA cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin (Cat. No. 586005). Inhibits Ca2+ uptake in cultured arterial smooth muscle cells (IC50 = 560 nM). Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase.
          Catalogue Number239805
          Brand Family Calbiochem®
          SynonymsCPA
          References
          ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
          Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
          Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
          Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
          Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
          Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
          Product Information
          CAS number18172-33-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₀N₂O₃
          Chemical formulaC₂₀H₂₀N₂O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCa2+ uptake in cultured arterial musclue cells
          Primary Target IC<sub>50</sub>560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUY8587000
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239805

          References

          Reference overview
          Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
          Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
          Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
          Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
          Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
          Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          SynonymsCPA
          DescriptionA cell-permeable, reversible inhibitor of endoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as thapsigargin. Mobilizes Ca2+ without increasing the levels of Ins(1,4,5)P3. Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca2+ pools that have been depleted by repetitive stimulation with acetylcholine.
          FormOff-white solid
          CAS number18172-33-3
          RTECSUY8587000
          Chemical formulaC₂₀H₂₀N₂O₃
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityChloroform (10 mg/ml) or DMSO (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
          Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
          Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
          Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
          Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
          Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.