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219428 | Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem

219428
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219428-1SET
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      Stocked 
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      Available
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          Glass bottle 1 set
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          Description
          OverviewContains 5 mg of Olomoucine (Cat. No. 495620), 1 mg of Iso-Olomoucine (Cat. No. 495622), and 1 mg of Roscovitine (Cat. No. 557360). Supplied with an informational insert.
          Catalogue Number219428
          Brand Family Calbiochem®
          References
          ReferencesMeijer, L. 1996. Trends in Cell Biol. 6, 393.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.
          Product Information
          FormSolid
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219428

          References

          Reference overview
          Meijer, L. 1996. Trends in Cell Biol. 6, 393.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-June-2008 RFH
          DescriptionThe eight cyclin-dependent protein kinases (Cdks) that have been identified to date play an essential role in the regulation of the cell cycle. Each Cdk is thought to be regulated by its transient association with one or more members of the cyclin family. These Cdk/cyclin complexes reportedly regulate each step of the cell cycle. For example, the G1/S transition is regulated by Cdk2/cyclin E, Cdk3/unknown cyclin, Cdk4/cyclin D1-3, Cdk6/cyclin D1, and Cdk8/cyclin C. The frequent deregulation of Cdks and their regulators in cancer has stimulated the search for potent and selective inhibitors of Cdks for both research and therapeutic use. Calbiochem® brand offers a set of two such inhibitors and a negative control compound. All three compounds are cell-permeable and act by competitively binding to the ATP binding site of the kinases.
          FormSolid
          Storage -20°C
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          ReferencesMeijer, L. 1996. Trends in Cell Biol. 6, 393.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.