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12-555 | Crosstide KK

1 mg  
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      Replacement Information
      Catalogue Number12-555
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCrosstide KK
      Product Information
      ApplicationCrosstide KK primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • SGK3
      • CISK
      • DKFZp781N0293
      • SGK2
      • SGKL
      Protein TargetSGK3
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96BR1 # Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals (By similarity).
      SIZE: 496 amino acids; 57108 Da
      SUBCELLULAR LOCATION: Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Note=Localized in vesicle-like structures and in the early endosome (By similarity).
      TISSUE SPECIFICITY: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle.
      SIMILARITY: SwissProt: Q96BR1 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. & Contains 1 PX (phox homology) domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation using SGK3, active (Catalog # 14-647).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 4°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Crosstide KK - 2502870 2502870
      Crosstide KK - 2196130 2196130
      Crosstide KK - 27121 27121
      Crosstide KK - DAM1482739 DAM1482739
      Crosstide KK - DAM1661100 DAM1661100
      Crosstide KK - JBC1915438 JBC1915438


      Reference overviewApplicationPub Med ID
      The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
      Konrad, D, et al.
      Diabetes, 50: 1464-71 (2001) 2001

      Show Abstract
      11375349 11375349
      GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase
      Somwar, R., et al
      Biochem J, 359:639-49 (2001) 2001

      Kinase Assay11672439 11672439
      Mechanism of activation of protein kinase B by insulin and IGF-1.
      Alessi, D R, et al.
      EMBO J., 15: 6541-51 (1996) 1996

      Show Abstract
      8978681 8978681

      Related Products & Applications

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates