234610 | Congo Red, High Purity - CAS 573-58-0 - Calbiochem

234610
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₂₂N₆O₆S₂ · 2Na 573-58-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234610-500MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 500 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewAn amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
          Catalogue Number234610
          Brand Family Calbiochem®
          Synonyms3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
          References
          ReferencesAltschuler, S.E., et al. 2012. Biochemistr in press.
          Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
          Fezoui, Y., et al. 2000. Amyloid 7, 166.
          Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
          Kramport, M., et al. 2000. Chem. Biol. 7, 855.
          Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
          Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
          Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
          Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.
          Product Information
          CAS number573-58-0
          ATP CompetitiveN
          FormRust crystalline solid
          Hill FormulaC₃₂H₂₂N₆O₆S₂ · 2Na
          Chemical formulaC₃₂H₂₂N₆O₆S₂ · 2Na
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAn amyloidophylic dye that specifically stains stacked β sheet aggregates
          Purity≥75% (dye content)
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQK1400000
          Safety Information
          S PhraseS: 25

          Avoid contact with eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          234610

          References

          Reference overview
          Altschuler, S.E., et al. 2012. Biochemistr in press.
          Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
          Fezoui, Y., et al. 2000. Amyloid 7, 166.
          Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
          Kramport, M., et al. 2000. Chem. Biol. 7, 855.
          Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
          Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
          Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
          Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-September-2012 JSW
          Synonyms3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
          DescriptionAn amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
          FormRust crystalline solid
          Recommended reaction conditionsDissolve 0.5 g Congo Red in 80 ml of absolute ethanol. To this solution add 20 ml of 10% NaCl solution (2 g/20 ml of water). Filter before use. Immerse coverslips containing cells or sections into this solution for 3 min at room temperature. Wash with several exchanges of distilled H2O until the water runs is clear. Dehydrate with ascending alcohol solutions (50%, 70%, 80%, 95% x 2, 100% x 2). Clear with 100% xylene. Mount coverslip onto slide using Permount or other suitable organic mounting medium and view under a microscope. Amyloid deposits will appear red to pink-red. With a polarizing microscope, amyloid deposits show an apple-green birefringence.
          CAS number573-58-0
          RTECSQK1400000
          Chemical formulaC₃₂H₂₂N₆O₆S₂ · 2Na
          Structure formulaStructure formula
          Purity≥75% (dye content)
          SolubilityEthanol or H₂O (10 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
          Toxicity Standard Handling
          Merck USA index14, 2498
          ReferencesAltschuler, S.E., et al. 2012. Biochemistr in press.
          Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
          Fezoui, Y., et al. 2000. Amyloid 7, 166.
          Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
          Kramport, M., et al. 2000. Chem. Biol. 7, 855.
          Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
          Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
          Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
          Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.