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204876 | Complement C1q, Human

204876
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      204876-1MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 1 mg
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          Description
          OverviewNative, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits, A, B, and C, of M.W. 29 kDa, 26 kDa, and 19 kDa, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
          Catalogue Number204876
          Brand Family Calbiochem®
          References
          ReferencesLoos, M., et al. 1980. J. Immunol. 124, 59.
          Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.
          Product Information
          CAS number80295-33-6
          FormLiquid
          FormulationIn 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.
          Applications
          Biological Information
          Biological activity≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
          Purity≥90% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          ContaminantsIgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin: ≤trace amounts
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          204876

          References

          Reference overview
          Loos, M., et al. 1980. J. Immunol. 124, 59.
          Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.

          Citations

          Title
        • Baruah, P., et al. 2006. Journal of Leukocyte Biology in press,.
        • Yuste, J., et al. 2006. Journal of Immunology 176, 6112.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-May-2008 RFH
          DescriptionNative, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits A, B, and C, of M.W. 29,000, 26,000 and 19,000, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
          FormLiquid
          FormulationIn 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number80295-33-6
          Purity≥90% by SDS-PAGE
          ContaminantsIgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin: ≤trace amounts
          Biological activity≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesLoos, M., et al. 1980. J. Immunol. 124, 59.
          Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.
          Citation
        • Baruah, P., et al. 2006. Journal of Leukocyte Biology in press,.
        • Yuste, J., et al. 2006. Journal of Immunology 176, 6112.