234200 Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

234200
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₀O₅ 117048-59-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234200-10MG
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          10 mg
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          Description
          OverviewA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
          Catalogue Number234200
          Brand Family Calbiochem®
          SynonymsNSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
          References
          ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
          Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
          Pettit, G.R., et al. 1989. Experientia 45, 209.
          Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
          Product Information
          CAS number117048-59-6
          FormOff-white solid
          Hill FormulaC₁₈H₂₀O₅
          Chemical formulaC₁₈H₂₀O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          234200

          References

          Reference overview
          Tron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
          Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
          Pettit, G.R., et al. 1989. Experientia 45, 209.
          Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2010 RFH
          SynonymsNSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
          DescriptionA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat. No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number117048-59-6
          Chemical formulaC₁₈H₂₀O₅
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
          Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
          Pettit, G.R., et al. 1989. Experientia 45, 209.
          Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.