234115 Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem

234115
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₅NO₆ 64-86-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234115-1GM
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          Alu drum 1 gm
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          234115-5GM
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              5 gm
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              Description
              OverviewInhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
              Catalogue Number234115
              Brand Family Calbiochem®
              References
              ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
              Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
              Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
              Santell, L. 1992. Exp. Cell Res. 201, 358.
              Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
              Product Information
              CAS number64-86-8
              ATP CompetitiveN
              FormYellow or off-white powder
              Hill FormulaC₂₂H₂₅NO₆
              Chemical formulaC₂₂H₂₅NO₆
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetInhibitor of mitosis
              Purity≥94% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSGH0700000
              Safety Information
              R PhraseR: 26/28

              Very toxic by inhalation and if swallowed.
              S PhraseS: 13-45

              Keep away from food, drink and animal feeding stuffs.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              234115

              References

              Reference overview
              Bonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
              Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
              Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
              Santell, L. 1992. Exp. Cell Res. 201, 358.
              Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision22-October-2009 RFH
              DescriptionMajor alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
              FormYellow or off-white powder
              CAS number64-86-8
              RTECSGH0700000
              Chemical formulaC₂₂H₂₅NO₆
              Structure formulaStructure formula
              Purity≥94% by HPLC
              SolubilityEthanol (10 mg/ml) or H₂O
              Storage +15°C to +30°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Merck USA index14, 2471
              ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
              Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
              Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
              Santell, L. 1992. Exp. Cell Res. 201, 358.
              Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.