234109 Colcemid - CAS 477-30-5 - Calbiochem

234109
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₅NO₅ 477-30-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234109-5MG
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          Alu drum 5 mg
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          Description
          OverviewCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
          Catalogue Number234109
          Brand Family Calbiochem®
          SynonymsDemecolcine
          References
          ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
          Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
          Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
          Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.
          Product Information
          CAS number477-30-5
          ATP CompetitiveN
          FormCrystalline powder
          Hill FormulaC₂₁H₂₅NO₅
          Chemical formulaC₂₁H₂₅NO₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDepolymerizes microtubules and limits microtubule formation.
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGH0800000
          Safety Information
          R PhraseR: 25-63

          Toxic if swallowed.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          234109

          References

          Reference overview
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
          Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
          Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
          Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          SynonymsDemecolcine
          DescriptionCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
          FormCrystalline powder
          CAS number477-30-5
          RTECSGH0800000
          Chemical formulaC₂₁H₂₅NO₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol and chloroform (10 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2887
          ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
          Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
          Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
          Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.