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12-556 | Cofilin 1

150 µg  
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      Replacement Information
      Catalogue Number12-556
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCofilin 1
      OverviewN-terminal GST-tagged recombinant human, full length cofilin 1
      Product Information
      ApplicationCofilin 1 primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryCofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM]
      Gene Symbol
      • CFL1
      • CFL
      • Cofilin-1
      • p18
      Purification MethodGlutathione-agarose
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23528 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
      SIZE: 166 amino acids; 18502 Da
      SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
      TISSUE SPECIFICITY: Widely distributed in various tissues.
      PTM: Phosphorylated on Ser-3 in resting cells (By similarity).
      SIMILARITY: SwissProt: P23528 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain.
      Molecular Weight44.9kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as a substrate in a kinase assay using LIM Kinase 1 (Catalog# 14-656).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size150 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Cofilin 1 - D8JN060AU D8JN060AU
      Cofilin 1 - D8JN060U-B D8JN060U-B
      Cofilin 1 - D8JN060U-C D8JN060U-C
      Cofilin 1 - D8JN060U-D D8JN060U-D


      Reference overviewPub Med ID
      High serum leptin is an independent risk factor for non-response patients with low viremia to antiviral treatment in chronic hepatitis C.
      Yuichiro Eguchi,Toshihiko Mizuta,Tsutomu Yasutake,Akitaka Hisatomi,Ryuichi Iwakiri,Iwata Ozaki,Kazuma Fujimoto
      World journal of gastroenterology : WJG 12 2006

      Show Abstract
      16489668 16489668
      Regulation of the neuronal actin cytoskeleton by ADF/cofilin.
      Sarmiere, Patrick D and Bamburg, James R
      J. Neurobiol., 58: 103-17 (2004) 2004

      Show Abstract
      14598374 14598374
      Signal transduction cascades underlying de novo protein synthesis required for neuronal morphogenesis in differentiating neurons.
      Tojima, Takuro and Ito, Etsuro
      Prog. Neurobiol., 72: 183-93 (2004) 2004

      Show Abstract
      15130709 15130709
      Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1: new blades for twisted filaments.
      Ono, Shoichiro
      Biochemistry, 42: 13363-70 (2003) 2003

      Show Abstract
      14621980 14621980
      Regulation of cortical actin networks in cell migration.
      Suetsugu, Shiro and Takenawa, Tadaomi
      Int. Rev. Cytol., 229: 245-86 (2003) 2003

      Show Abstract
      14669958 14669958

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