233526 | Coagulation Factor Xa, Human Plasma

233526
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233526-10U
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          Plastic ampoule 10 u
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          Description
          OverviewNative coagulation factor Xa from human plasma prepared from homogeneous Factor X by activation with Russel’s viper venom. The venom is removed after activation. During coagulation, in the presence of Ca2+ and membrane phospholipids, a complex of Factor Xa and Factor Va (the prothrombinase complex) activates prothrombin to thrombin. Inhibitors include AEBSF (Cat. No. 101500), DFP (Cat. No. 30967), PMSF (Cat. No. 52332), and Soybean Trypsin Inhibitor (Cat. No. 650357). Sold on the basis of plasma equivalent units of Factor X. 100 plasma equivalent units are equal to 800 µg of Factor X.
          Catalogue Number233526
          Brand Family Calbiochem®
          References
          ReferencesHeeb, M.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2728.
          Lindhout, T., et al. 1994. Biochem. J. 297, 131.
          Morishita, H., et al. 1994. Thrombosis Res. 73, 193.
          Lupu, C., et al. 1993. Thrombosis Haemostasis 70, 579.
          Jordan, S.P., et al. 1992. Biochemistry 31, 5374.
          Schoen, P., et al. 1992. Br. J. Haemotol. 81, 255.
          Tracy, P.B., et al. 1992. Methods Enzymol. 215, 329.
          Lawson, J.H., and Mann, K.G. 1991. J. Biol. Chem. 226, 11317.
          Tans, G., et al. 1991. J. Biol. Chem. 266, 21864.
          Owen, W.G., et al. 1974. J. Biol. Chem. 249, 594.
          Product Information
          CAS number9002-05-5
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol CHROMOZYM<sup>®</sup> X substrate per min at 25°C.
          EC number3.4.21.6
          FormLyophilized
          FormulationLyophilized from 700 mM NaCl, 20 mM Tris-HCl, pH 7.4.
          Applications
          Biological Information
          Purityhomogeneous by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥170 units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233526

          References

          Reference overview
          Heeb, M.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2728.
          Lindhout, T., et al. 1994. Biochem. J. 297, 131.
          Morishita, H., et al. 1994. Thrombosis Res. 73, 193.
          Lupu, C., et al. 1993. Thrombosis Haemostasis 70, 579.
          Jordan, S.P., et al. 1992. Biochemistry 31, 5374.
          Schoen, P., et al. 1992. Br. J. Haemotol. 81, 255.
          Tracy, P.B., et al. 1992. Methods Enzymol. 215, 329.
          Lawson, J.H., and Mann, K.G. 1991. J. Biol. Chem. 226, 11317.
          Tans, G., et al. 1991. J. Biol. Chem. 266, 21864.
          Owen, W.G., et al. 1974. J. Biol. Chem. 249, 594.

          Brochure

          Title
          Coagulation Factors Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-March-2009 JSW
          DescriptionNative coagulation factor Xa from human plasma prepared from homogeneous Factor X by activation with Russel’s viper venom. Hydrolyzes peptide and ester bonds at the carboxyl group of arginine. Specifically catalyzes the activation of prothrombin to thrombin. Prothrombin activation is accelerated by Factor Va, phospholipids, and Ca2+. Factor Xa was prepared from homogeneous Factor X, using Russels' viper venom (RVV), which was removed after activation. Inhibited by AEBSF (Cat. No. 101500), DFP (Cat. No. 30967), PMSF (Cat. No. 52332), and soybean trypsin inhibitor (Cat. No. 650357). Sold on the basis of plasma equivalent units of Factor X. 100 plasma equivalent units are equal to 800 µg of Factor X.
          FormLyophilized
          FormulationLyophilized from 700 mM NaCl, 20 mM Tris-HCl, pH 7.4.
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9002-05-5
          EC number3.4.21.6
          Purityhomogeneous by SDS-PAGE
          Specific activity≥170 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol CHROMOZYM® X substrate per min at 25°C.
          SolubilityH₂O.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesHeeb, M.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2728.
          Lindhout, T., et al. 1994. Biochem. J. 297, 131.
          Morishita, H., et al. 1994. Thrombosis Res. 73, 193.
          Lupu, C., et al. 1993. Thrombosis Haemostasis 70, 579.
          Jordan, S.P., et al. 1992. Biochemistry 31, 5374.
          Schoen, P., et al. 1992. Br. J. Haemotol. 81, 255.
          Tracy, P.B., et al. 1992. Methods Enzymol. 215, 329.
          Lawson, J.H., and Mann, K.G. 1991. J. Biol. Chem. 226, 11317.
          Tans, G., et al. 1991. J. Biol. Chem. 266, 21864.
          Owen, W.G., et al. 1974. J. Biol. Chem. 249, 594.