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233501 | Coagulation Factor XIII, Human Plasma

233501
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233501-100UG
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          Glass bottle 100 μg
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          Description
          OverviewNative coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α2β2) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α2β2 tetramer to a modified α2′β2 tetramer, Ca2+ promotes both the dissociation of the β2 dimer and the activation of the α2′ dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.
          Catalogue Number233501
          Brand Family Calbiochem®
          SynonymsFibrin-stabilizing Factor
          References
          Product Information
          CAS number9013-56-3
          Unit of DefinitionClotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.
          FormLiquid
          FormulationIn 500 µM EDTA, 50% glycerol.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥40 units/mg protein (clotting assay)
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233501

          Brochure

          Title
          Coagulation Factors Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          SynonymsFibrin-stabilizing Factor
          DescriptionNative coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α2β2) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α2β2 tetramer to a modified α2'β2 tetramer, Ca2+ promotes both the dissociation of β2 dimer and the activation of the α2' dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.
          FormLiquid
          FormulationIn 500 µM EDTA, 50% glycerol.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9013-56-3
          Purity≥95% by SDS-PAGE
          Specific activity≥40 units/mg protein (clotting assay)
          Unit definitionClotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          Merck USA index14, 3926