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233165 | Clioquinol - CAS 130-26-7 - Calbiochem

233165
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₅ClINO 130-26-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233165-1GM
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          Plastic Bag(s) 1 gm
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          Description
          OverviewA metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.
          Catalogue Number233165
          Brand Family Calbiochem®
          Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
          References
          ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
          Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
          Helmuth, L., et al. 2000. Science 290, 1273.
          Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.
          Product Information
          CAS number130-26-7
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₉H₅ClINO
          Chemical formulaC₉H₅ClINO
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetMetal ion chelator
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSVC5075000
          Safety Information
          R PhraseR: 42/43-63

          May cause sensitization by inhalation and skin contact.
          Possible risk of harm to the unborn child.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233165

          References

          Reference overview
          Melov, S. 2002. Trends Neurosci. 25, 121.
          Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
          Helmuth, L., et al. 2000. Science 290, 1273.
          Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.

          Brochure

          Title
          Antibiotics Profiler
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
          DescriptionA metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid's ability to clump together, apparently by trapping the Cu2+ and Zn2+ that reduces the build-up of these deposits. Exhibits greater affinity for Cu2+ and Zn2+ than for Ca2+ and Mg2+. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer's disease.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number130-26-7
          RTECSVC5075000
          Chemical formulaC₉H₅ClINO
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml), Ethanol (1 mg/ml) or Methanol (1.5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 5031
          ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
          Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
          Helmuth, L., et al. 2000. Science 290, 1273.
          Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.