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232120 | Cisplatin - CAS 15663-27-1 - Calbiochem

232120
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      Pt(NH₃)₂Cl₂ 15663-27-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      232120-50MG
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          Glass bottle 50 mg
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          Description
          OverviewA platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

          Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
          Catalogue Number232120
          Brand Family Calbiochem®
          SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
          References
          ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
          Duan, L., et al. 2001. J. Neurooncol. 52, 23.
          Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
          Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
          Product Information
          CAS number15663-27-1
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaPt(NH₃)₂Cl₂
          Chemical formulaPt(NH₃)₂Cl₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetInduces apoptosis in cancer cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSTP2450000
          Safety Information
          R PhraseR: 25-36/37/38-45-42/43

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause cancer.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 22-24-37-45-53

          Do not breathe dust.
          Avoid contact with skin.
          Wear suitable gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          232120

          References

          Reference overview
          Hall, M.D., et al. 2014. Cancer Res. In press.
          Duan, L., et al. 2001. J. Neurooncol. 52, 23.
          Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
          Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-July-2014 JSW
          SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
          DescriptionA platinum coordination complex with potent antineoplastic activity.

          Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
          FormYellow solid
          CAS number15663-27-1
          RTECSTP2450000
          Chemical formulaPt(NH₃)₂Cl₂
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml), H₂O with 154 mM NaCl (1 mg/ml), or PBS with 140 mM NaCl (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2317
          ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
          Duan, L., et al. 2001. J. Neurooncol. 52, 23.
          Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
          Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.