220486 Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

220486
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₄ClN₃O₂ 516480-79-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      220486-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491).
          Catalogue Number220486
          Brand Family Calbiochem®
          Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
          References
          ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
          Product Information
          CAS number516480-79-8
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₂₀H₁₄ClN₃O₂
          Chemical formulaC₂₀H₁₄ClN₃O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetChk2
          Primary Target IC<sub>50</sub>15 nM; Ki = 37 nM inhibiting Chk2; EC50 = 3 µM and 7.6 µM in rescuing both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis
          Primary Target K<sub>i</sub>37 nM inhibiting Chk2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          220486

          References

          Reference overview
          Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-December-2009 RFH
          Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
          DescriptionA cell-permeable, potent, reversible and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number516480-79-8
          Chemical formulaC₂₀H₁₄ClN₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.