A part of MilliporeSigma

CC118 | Chicken Tenascin

50 µg  
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      Replacement Information

      Key Specifications Table

      Key Applications
      PC, CULT
      Catalogue NumberCC118
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionChicken Tenascin
      OverviewTenascin is a large glycoprotein that forms disulfide-linked hexamers. It is made up of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels. Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays.
      Alternate Names
      • Cytotactin
      • Tenascin-C
      Product Information
      PresentationProvided as a liquid in PBS, containing no preservatives.
      Key Applications
      • Positive Control
      • Cell Culture
      Biological Information
      Concentration0.5 mg/mL
      PurityIsolated from embryonic chicken brains by chromatographic methods. Contains three characteristic polypeptide chains (220, 200, and 190 kDa) that migrate on SDS gels as a high molecular weight multimer under non-reducing conditions.
      SourcePurified from embrionic chicken brains.
      UniProt Number
      Stem Cell Type
      • Mouse Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 12 months. Avoid repeated freeze/thaw.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      CHICKEN TENASCIN -2615117 2615117
      Chicken Tenascin Purified Protein 2472937


      Reference overviewPub Med ID
      Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments.
      Spring, J, et al.
      Cell, 59: 325-34 (1989) 1989

      Show Abstract
      2478295 2478295
      A detailed structural model of cytotactin: protein homologies, alternative RNA splicing, and binding regions
      Jones, F S, et al
      Proc Natl Acad Sci USA, 86:1905-9 (1989) 1989

      2467292 2467292