Key Specifications Table
|Presentation||Provided as a liquid in PBS, containing no preservatives.|
|Safety Information according to GHS|
|Storage and Shipping Information|
|Storage Conditions||Store at -20°C for up to 12 months. Avoid repeated freeze/thaw.|
|Material Size||50 µg|
|CHICKEN TENASCIN -2615117||2615117|
|Chicken Tenascin Purified Protein||2472937|
|Reference overview||Pub Med ID|
|Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments. |
Spring, J, et al.
Cell, 59: 325-34 (1989) 1989
A structural and functional model of tenascin was elaborated using recombinant parts of three alternatively spliced tenascin variants and anti-tenascin monoclonal antibodies. The fusion proteins were compared with intact tenascin for their functions and by electron microscopy. A strong cell binding site was localized within 104 amino acids. This fragment also contains the epitope of the monoclonal antibody anti-Tn68, which inhibits cell attachment to tenascin and binds near the tips of the six arms of tenascin. In contrast, constructs containing the 13 1/2 EGF-like repeats of tenascin showed an antiadhesive effect. The coexistence of the two contrary signals on the same molecule might be responsible for the versatile features of tenascin.
|A detailed structural model of cytotactin: protein homologies, alternative RNA splicing, and binding regions |
Jones, F S, et al
Proc Natl Acad Sci USA, 86:1905-9 (1989) 1989