220320 | Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

220320
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₃₀N₆O₆S₄ 1403-36-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      220320-1MG
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          Description
          OverviewA cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
          Catalogue Number220320
          Brand Family Calbiochem®
          SynonymsCS-1, CTM
          References
          ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
          Kung, A.L., et al. 2004. Cancer Cell 6, 33.
          Product Information
          CAS number1403-36-7
          FormOff-white solid
          Hill FormulaC₃₁H₃₀N₆O₆S₄
          Chemical formulaC₃₁H₃₀N₆O₆S₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSFM3038000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          220320

          References

          Reference overview
          Fujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
          Kung, A.L., et al. 2004. Cancer Cell 6, 33.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2009 RFH
          SynonymsCS-1, CTM
          DescriptionA cell-permeable antimicrobial that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation. Prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and <10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Exhibits no effect on the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1403-36-7
          RTECSFM3038000
          Chemical formulaC₃₁H₃₀N₆O₆S₄
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
          Kung, A.L., et al. 2004. Cancer Cell 6, 33.