Key Specifications Table
|Species||Host Cells||Protein Target|
|Application||Human 5-HT6 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.|
|Application Notes||Radioligand binding assay and GTPγS binding.|
|Safety Information according to GHS|
|Storage and Shipping Information|
|Storage Conditions||Maintain frozen at –70°C up to expiration date indicated on the label. Do not freeze and thaw.|
|Material Size||200 units|
ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT6 Serotonin Receptor SDS
ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT6 Serotonin Receptor Certificates of Analysis
|CHEMISCREENTM MEMBRANE PREPARATION RECOMBINANT HUMAN 5-HT6 SERATONIN RECEPTOR - 2324477||2324477|
|Reference overview||Pub Med ID|
|Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.|
Fisas, Angels, et al.
Br. J. Pharmacol., 148: 973-83 (2006) 2006
Woolley, Marie L, et al.
Current drug targets. CNS and neurological disorders, 3: 59-79 (2004) 2004
The 5-hydroxytryptamine(6) (5-ht(6)) was one of the most recent additions to the 5-HT receptor family, selective antagonists have recently been developed and potential functional roles are now becoming apparent. The high affinity of a wide range of psychiatric drugs for the 5-ht(6)receptor, together with its almost exclusive expression in the CNS, being abundant in limbic and cortical regions, has stimulated significant research interest. The 5-ht(6)receptor appears to regulate glutamatergic and cholinergic neuronal activity, and increasing evidence suggests that it may be involved in the regulation of cognition, feeding and, possibly, affective state and seizures. The current article will review all aspects of the discovery, genetics, distribution, pharmacology and function of the 5-ht(6)receptor. Taken together, this wealth of information warrants the use of the upper case nomenclature for the 5-ht(6) receptor to be approved and its true status recognised.
|CHEMISCREENTM MEMBRANE PREPARATION RECOMBINANT HUMAN 5-HT6 SERATONIN RECEPTOR|
|CHEMISCREEN™ MEMBRANE PREPARATION HUMAN RECOMBINANT 5-HT6 SEROTONIN RECEPTOR|