14-519M | Cdk6/Cyclin D3 Protein, active, 250 µg

14-519M
250 µg  Also available in 10 μg size (cat#14-519) and in bulk (cat# 14-519-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-519M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCdk6/Cyclin D3 Protein, active, 250 µg
      OverviewN-terminal, His6-tagged fulllength human cdk6 complexed with N-terminal GSTtagged full-length human cyclin D3
      References
      Product Information
      Applications
      ApplicationActive, N-terminal, His6-tagged full length human Cdk6 complexed with N-terminal GST-tagged full-length human Cyclin D3, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
      Gene Symbol
      • CDK6
      • PLSTIRE
      • MGC59692
      Protein TargetCDK6/cyclinD3
      Purification MethodGlutathione-agarose
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q00534 # Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
      SIZE: 326 amino acids; 36938 Da
      SIMILARITY: SwissProt: Q00534 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
      Molecular Weight38kDa (cdk6) and 59kDa (cyclin D3)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of histone H1
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-519) and in bulk (cat# 14-519-K).
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-519 Cdk6/Cyclin D3 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases