238806 Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem

238806
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₂N₆O₂S 507487-89-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      238806-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
          Catalogue Number238806
          Brand Family Calbiochem®
          Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
          References
          ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
          Wang, S., et al. 2004. J. Med. Chem. 47, 1662.
          Product Information
          CAS number507487-89-0
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₄H₁₂N₆O₂S
          Chemical formulaC₁₄H₁₂N₆O₂S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCdk2/E and Cdk9/T1
          Primary Target K<sub>i</sub>2 nM and 4 nM against Cdk2/E and Cdk9/T1, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          238806

          References

          Reference overview
          Kontopidis, G., et al. 2006. Chem. Biol. 13, 201.
          Wang, S., et al. 2004. J. Med. Chem. 47, 1662.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
          DescriptionA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number507487-89-0
          Chemical formulaC₁₄H₁₂N₆O₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
          Wang, S., et al. 2004. J. Med. Chem. 47, 1662.