217713 | Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

217713
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₂N₆O₃S 444722-95-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      217713-1MG
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          Plastic ampoule 1 mg
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          217713-5MG
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              Description
              OverviewA cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
              Catalogue Number217713
              Brand Family Calbiochem®
              Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
              References
              ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
              Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
              Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
              Product Information
              CAS number444722-95-6
              ATP CompetitiveY
              FormWhite solid
              Hill FormulaC₁₈H₂₂N₆O₃S
              Chemical formulaC₁₈H₂₂N₆O₃S
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetCdk1/cyclin B, Cdk2/cyclin A3
              Primary Target IC<sub>50</sub>9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              217713

              References

              Reference overview
              Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
              Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
              Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.

              Brochure

              Title
              DNA Repair Pathway Poster
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision05-April-2011 RFH
              Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
              DescriptionA cell-permeable purine analog that displays anti-proliferative properties and acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM, respectively). Displays greater selectivity for Cdk's over other kinases tested (IC50 = 30 nM, 600 nM, 800 nM, 900 nM, and 1.6 µM for Cdk2/A, ROCKII, PDK1, DYRK1A, and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth (GI50 of 8 µM).
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number444722-95-6
              Chemical formulaC₁₈H₂₂N₆O₃S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (20 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
              Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
              Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.