A part of MilliporeSigma

217695 | Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

217695
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₁ClN₂O 220749-41-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      217695-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 µM). Also inhibits Cdk5 with a IC50 = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.
          Catalogue Number217695
          Brand Family Calbiochem®
          Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
          References
          ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
          Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
          Product Information
          CAS number220749-41-7
          ATP CompetitiveY
          FormOrange solid
          Hill FormulaC₁₇H₁₁ClN₂O
          Chemical formulaC₁₇H₁₁ClN₂O
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCdk1
          Primary Target IC<sub>50</sub>2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          217695

          References

          Reference overview
          Andreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
          Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-December-2009 RFH
          Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
          DescriptionA cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM in HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of cyclin-dependent kinase-1/cyclin B (IC50 = 5.8 µM for Cdk1 and 25 µM for Cdk5). Does not affect the activity of GSK-3β even at 100 µM concentrations. Binds to the ATP pocket in the Cdk1 active site.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220749-41-7
          Chemical formulaC₁₇H₁₁ClN₂O
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
          Andreani, A., et al. 1996. Anticancer Res. 16, 3585.