219393 | Cathepsin S Inhibitor - Calbiochem

219393
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₂₈N₂O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219393-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
          Catalogue Number219393
          Brand Family Calbiochem®
          SynonymsZ-FL-COCHO
          References
          ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
          Product Information
          ATP CompetitiveN
          Formpale yellow solid
          Hill FormulaC₂₄H₂₈N₂O₅
          Chemical formulaC₂₄H₂₈N₂O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).
          Biological Information
          Primary Targetcathepsin S
          Primary Target K<sub>i</sub>185 pM against cathepsin S
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Phe-Leu-COCHO • H₂O
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219393

          References

          Reference overview
          Walker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-November-2009 RFH
          SynonymsZ-FL-COCHO
          DescriptionA dipeptidyl α-keto-β-aldehyde that acts as a slow, tight-binding, highly potent, reversible inhibitor of cathepsin S. Exhibits over 410-fold greater selectivity for cathepsin S (Ki = 185 pM) over cathepsin B (Ki = 76 nM).
          Formpale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₂₈N₂O₅
          Peptide SequenceZ-Phe-Leu-COCHO • H₂O
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.