219343 Cathepsin S, Human, Recombinant, E. coli

219343
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219343-25UG
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          Plastic ampoule 25 μg
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          Description
          OverviewRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase preferentially expressed in macrophages and microglia. Exhibits high specific activity.
          Note: 1 mU = 1 milliunit.
          Catalogue Number219343
          Brand Family Calbiochem®
          References
          ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
          Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
          Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
          Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
          Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
          Kirschke, H., et al. 1989. Biochem. J. 264, 467.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
          EC number3.4.22.27
          FormLiquid
          FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          Specific Activity≥30,000 mU/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219343

          References

          Reference overview
          Liuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
          Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
          Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
          Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
          Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
          Kirschke, H., et al. 1989. Biochem. J. 264, 467.

          Citations

          Title
        • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-September-2007 RFH
          DescriptionRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
          FormLiquid
          FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
          EC number3.4.22.27
          Purity≥90% by SDS-PAGE
          Specific activity≥30,000 mU/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Harmful
          ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
          Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
          Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
          Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
          Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
          Kirschke, H., et al. 1989. Biochem. J. 264, 467.
          Citation
        • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.