219419 | Cathepsin Inhibitor III - Calbiochem

219419
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₂₇N₃O₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219419-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1).
          Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
          Catalogue Number219419
          Brand Family Calbiochem®
          SynonymsZ-FG-NHO-BzOME
          References
          ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
          Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₇H₂₇N₃O₇
          Chemical formulaC₂₇H₂₇N₃O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcathepsin B
          Primary Target K<sub>i</sub>k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹
          Purity>90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Phe-Gly-NHO-Bz-pOMe
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219419

          References

          Reference overview
          Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
          Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2007 RFH
          SynonymsZ-FG-NHO-BzOME
          DescriptionCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
          FormWhite solid
          Chemical formulaC₂₇H₂₇N₃O₇
          Peptide SequenceZ-Phe-Gly-NHO-Bz-pOMe
          Structure formulaStructure formula
          Purity>90% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
          Storage +15°C to +30°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
          Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.