342000 | Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

342000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₃FN₂O₄ 105637-38-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      342000-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
          Catalogue Number342000
          Brand Family Calbiochem®
          SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
          References
          ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
          Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
          Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
          Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
          Rauber, P., et al. 1986. Biochem. J. 239, 633.
          Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
          Rasnick, D. 1985. Anal. Biochem. 149, 461.
          Product Information
          CAS number105637-38-5
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₁H₂₃FN₂O₄
          Chemical formulaC₂₁H₂₃FN₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCathepsin-B
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Phe-Ala-FMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          342000

          References

          Reference overview
          Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
          Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
          Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
          Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
          Rauber, P., et al. 1986. Biochem. J. 239, 633.
          Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
          Rasnick, D. 1985. Anal. Biochem. 149, 461.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin

          Citations

          Title
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
          DescriptionA cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.
          FormOff-white solid
          CAS number105637-38-5
          Chemical formulaC₂₁H₂₃FN₂O₄
          Peptide SequenceZ-Phe-Ala-FMK
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
          Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
          Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
          Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
          Rauber, P., et al. 1986. Biochem. J. 239, 633.
          Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
          Rasnick, D. 1985. Anal. Biochem. 149, 461.
          Citation
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.