342000 | Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

342000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₃FN₂O₄ 105637-38-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      342000-1MG
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          Plastic ampoule 1 mg
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          342000-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
              Catalogue Number342000
              Brand Family Calbiochem®
              SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
              References
              ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
              Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
              Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
              Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
              Rauber, P., et al. 1986. Biochem. J. 239, 633.
              Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
              Rasnick, D. 1985. Anal. Biochem. 149, 461.
              Product Information
              CAS number105637-38-5
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₂₁H₂₃FN₂O₄
              Chemical formulaC₂₁H₂₃FN₂O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetCathepsin-B
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Phe-Ala-FMK
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              342000

              References

              Reference overview
              Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
              Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
              Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
              Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
              Rauber, P., et al. 1986. Biochem. J. 239, 633.
              Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
              Rasnick, D. 1985. Anal. Biochem. 149, 461.

              Brochure

              Title
              Cathepsins and Related Products Technical Bulletin

              Citations

              Title
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-April-2008 RFH
              SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
              DescriptionA cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.
              FormOff-white solid
              CAS number105637-38-5
              Chemical formulaC₂₁H₂₃FN₂O₄
              Peptide SequenceZ-Phe-Ala-FMK
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (10 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
              Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
              Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
              Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
              Rauber, P., et al. 1986. Biochem. J. 239, 633.
              Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
              Rasnick, D. 1985. Anal. Biochem. 149, 461.
              Citation
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.