218759 Caspase-8 Inhibitor II - Calbiochem

218759
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₄₃FN₄O₁₁

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218759-1MG
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          Plastic ampoule 1 mg
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          218759-250UG
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              Glass bottle 250 μg
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              Description
              OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
              Catalogue Number218759
              Brand Family Calbiochem®
              SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
              References
              ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
              Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
              Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Product Information
              ATP CompetitiveN
              FormWhite to yellow powder
              Hill FormulaC₃₀H₄₃FN₄O₁₁
              Chemical formulaC₃₀H₄₃FN₄O₁₁
              ReversibleN
              Applications
              ApplicationCaspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
              Biological Information
              Primary Targetcaspase-8
              Puritysingle spot by TLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              218759

              References

              Reference overview
              Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
              Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
              Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

              Citations

              Title
            • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
            • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
            • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
            • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
            • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-February-2011 JSW
              SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
              DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
              FormWhite to yellow powder
              Chemical formulaC₃₀H₄₃FN₄O₁₁
              Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
              Puritysingle spot by TLC
              SolubilityDMSO (10 mM)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
              Toxicity Standard Handling
              ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
              Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
              Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Citation
            • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
            • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
            • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
            • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
            • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.