218832 | Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem

218832
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₁N₅O₁₀ 775289-20-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218832-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
          Catalogue Number218832
          Brand Family Calbiochem®
          SynonymsAc-DNLD-CHO
          References
          ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
          Product Information
          CAS number775289-20-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₃₁N₅O₁₀
          Chemical formulaC₂₀H₃₁N₅O₁₀
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcaspase-3, caspase-7
          Primary Target IC<sub>50</sub>3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
          PuritySingle main spot with additional trace spot by TLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218832

          References

          Reference overview
          Yoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsAc-DNLD-CHO
          DescriptionA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
          Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number775289-20-8
          Chemical formulaC₂₀H₃₁N₅O₁₀
          Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
          Structure formulaStructure formula
          PuritySingle main spot with additional trace spot by TLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.