264150 | Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 - Calbiochem

264150
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      264150-1MG
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          Plastic ampoule 1 mg
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          264150-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewFluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
              Catalogue Number264150
              Brand Family Calbiochem®
              SynonymsZ-DEVD-AFC
              References
              ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Kluck, R.M., et al. 1997. Science 275, 1132.
              Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
              Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Product Information
              CAS number1177935-21-5
              ATP CompetitiveN
              FormWhite or off-white solid
              Hill FormulaC₃₆H₃₈F₃N₅O₁₄
              Chemical formulaC₃₆H₃₈F₃N₅O₁₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetFluorogenic caspase-3 substrate.
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Emission max.
              Excitation max.
              Peptide SequenceZ-Asp-Glu-Val-Asp-AFC
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              264150

              References

              Reference overview
              Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Kluck, R.M., et al. 1997. Science 275, 1132.
              Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
              Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision31-March-2011 RFH
              SynonymsZ-DEVD-AFC
              DescriptionFluorogenic CPP-32/apopain substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Excitation max: ~400 nm; emission max: ~505 nm.
              FormWhite or off-white solid
              CAS number1177935-21-5
              Chemical formulaC₃₆H₃₈F₃N₅O₁₄
              Peptide SequenceZ-Asp-Glu-Val-Asp-AFC
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml)
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Kluck, R.M., et al. 1997. Science 275, 1132.
              Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
              Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
              Nicholson, D.W., et al. 1995. Nature 376, 37.