235425 | Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem

235425
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      235425-1MG
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          Plastic ampoule 1 mg
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          235425-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewFluorogenic caspase-3 substrate. Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
              Catalogue Number235425
              Brand Family Calbiochem®
              SynonymsAc-DEVD-AMC
              References
              ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Product Information
              CAS number169332-61-0
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₃₀H₃₇N₅O₁₃
              Chemical formulaC₃₀H₃₇N₅O₁₃
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetFluorogenic caspase-3 substrate
              Primary Target IC<sub>50</sub>Km = 9.7 ± 1.0 µM for cleavage of this substrate by caspase-3
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Emission max.
              Excitation max.
              Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              235425

              References

              Reference overview
              Hermission, M., et al. 2000. Oncogene 19, 2338.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision31-March-2011 RFH
              SynonymsAc-DEVD-AMC
              DescriptionFluorogenic CPP32/Apopain substrate. Cleavage of this substrate by CPP32/Apopain shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Cleavage can be monitored by excitation at 380 nm and emission at 460 nm.
              FormOff-white solid
              CAS number169332-61-0
              Chemical formulaC₃₀H₃₇N₅O₁₃
              Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mM)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Nicholson, D.W., et al. 1995. Nature 376, 37.