400012 | Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

400012
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₃₃ClN₄O₈ 178603-78-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400012-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
          Catalogue Number400012
          Brand Family Calbiochem®
          SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
          References
          ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Enari, M., et al. 1995. Nature 375, 78.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Thornberry, N., et al. 1992. Nature 356, 768.
          Product Information
          CAS number178603-78-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₄H₃₃ClN₄O₈
          Chemical formulaC₂₄H₃₃ClN₄O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCaspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.
          Biological Information
          Primary Targetcaspase-1
          Primary Target K<sub>i</sub>760 pM against caspase-1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400012

          References

          Reference overview
          Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Enari, M., et al. 1995. Nature 375, 78.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Thornberry, N., et al. 1992. Nature 356, 768.

          Citations

          Title
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-November-2010 JSW
          SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
          DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
          FormWhite solid
          CAS number178603-78-6
          Chemical formulaC₂₄H₃₃ClN₄O₈
          Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Enari, M., et al. 1995. Nature 375, 78.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Thornberry, N., et al. 1992. Nature 356, 768.
          Citation
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors