505766 | Casein Kinase II Inhibitor XII, TBBz - CAS 577779-57-8 - Calbiochem

505766
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₂Br₄N₂ 577779-57-8

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      5.05766.0001
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          Glass bottle 20 mg
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          Description
          OverviewA cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a′ subunits is significantly reduced (Ki = 510 and 400 nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ˜25 µM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model.
          Catalogue Number505766
          Brand Family Calbiochem®
          Synonyms4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz
          References
          ReferencesSzyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
          Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
          Luo, W. et al. 2013. Cancer Res. 73, 2289.
          Product Information
          CAS number577779-57-8
          FormOff-white powder
          Hill FormulaC₇H₂Br₄N₂
          Chemical formulaC₇H₂Br₄N₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCK2
          Primary Target K<sub>i</sub>70 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Szyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
          Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
          Luo, W. et al. 2013. Cancer Res. 73, 2289.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-October-2013 JSW
          Synonyms4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz
          DescriptionA cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a′ subunits is significantly reduced (Ki = 510 and 400 nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ˜25 µM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number577779-57-8
          Chemical formulaC₇H₂Br₄N₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSzyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
          Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
          Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
          Luo, W. et al. 2013. Cancer Res. 73, 2289.