218714 | Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem

218714
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₂N₂O₃ 391670-48-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218714-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable indoloquinazolinone compound that acts as a potent, selective, reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
          Catalogue Number218714
          Brand Family Calbiochem®
          Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
          References
          ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
          Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
          Product Information
          CAS number391670-48-7
          FormLight yellow solid
          Hill FormulaC₁₇H₁₂N₂O₃
          Chemical formulaC₁₇H₁₂N₂O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218714

          References

          Reference overview
          Piazza, F.A., et al. 2006. Blood 108, 1698.
          Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-August-2017 JSW
          Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
          DescriptionA cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number391670-48-7
          Chemical formulaC₁₇H₁₂N₂O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
          Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
          Sarno, S., et al. 2003. Biochem. J. 374, 639.
          Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.