218697 Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem

218697
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆HBr₄N₃ 17374-26-4
      Description
      OverviewA cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
      Catalogue Number218697
      Brand Family Calbiochem®
      SynonymsTBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
      References
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
      Product Information
      CAS number17374-26-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₆HBr₄N₃
      Chemical formulaC₆HBr₄N₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      ApplicationCasein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2).
      Biological Information
      Primary TargetCK2 rat liver, human recombinant
      Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; < 1 µM for DYRK1a
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      218697

      References

      Reference overview
      Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-January-2009 JSW
      SynonymsTBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
      DescriptionA cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number17374-26-4
      Chemical formulaC₆HBr₄N₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Ruzzene, M., et al. 2002. Biochem. J. 364, 41.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.