215911 | Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

215911
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      555-60-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      215911-250MG
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          Plastic ampoule 250 mg
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          Description
          OverviewProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
          Catalogue Number215911
          Brand Family Calbiochem®
          SynonymsCCCP
          References
          ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
          Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
          Product Information
          CAS number555-60-2
          ATP CompetitiveN
          FormYellow solid
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.
          Biological Information
          Primary Targetcytochrome c oxydase
          Primary Target IC<sub>50</sub>Kd = 270 nM in binding with cytochrome c oxidase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSFG5600000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          215911

          References

          Reference overview
          Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
          Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.

          Brochure

          Title
          Mitochondrial Metabolism Modulators (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsCCCP
          DescriptionProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. ~100 times more effective than 2,4-dinitrophenol. Binds cytochrome C oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
          FormYellow solid
          CAS number555-60-2
          RTECSFG5600000
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Etthanol (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
          Toxicity Harmful
          ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
          Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.