211875 Captopril - CAS 62571-86-2 - Calbiochem

211875
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₅NO₃S 62571-86-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      211875-1GM
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          Plastic ampoule 1 gm
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          Description
          OverviewAn antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
          Catalogue Number211875
          Brand Family Calbiochem®
          Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
          References
          ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
          Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
          Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
          Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
          Kostis, J. 1988. Am. Heart J. 116, 1591.
          Product Information
          CAS number62571-86-2
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₉H₁₅NO₃S
          Chemical formulaC₉H₁₅NO₃S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetACE
          Primary Target IC<sub>50</sub>23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells
          Purity≥98% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUY0550000
          Safety Information
          R PhraseR: 63-43

          Possible risk of harm to the unborn child.
          May cause sensitization by skin contact.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          211875

          References

          Reference overview
          Uhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
          Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
          Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
          Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
          Kostis, J. 1988. Am. Heart J. 116, 1591.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
          DescriptionAn antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.
          FormWhite to off-white solid
          CAS number62571-86-2
          RTECSUY0550000
          Chemical formulaC₉H₁₅NO₃S
          Structure formulaStructure formula
          Purity≥98% by titration
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 1774
          ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
          Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
          Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
          Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
          Kostis, J. 1988. Am. Heart J. 116, 1591.