390238 Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem

A cell-permeable powerful DNA topoisomerase I inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 10-Hydroxycamptothecin, HCPT

Primary Target: DNA topoisomerase I
390238
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₆N₂O₅ 64439-81-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      390238-25MG
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          		 Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
          Catalogue Number390238
          Brand Family Calbiochem®
          Synonyms10-Hydroxycamptothecin, HCPT
          References
          ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
          Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
          Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
          Product Information
          CAS number64439-81-2
          ATP CompetitiveN
          FormPale yellow powder
          Hill FormulaC₂₀H₁₆N₂O₅
          Chemical formulaC₂₀H₁₆N₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA topoisomerase I
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          390238

          References

          Reference overview
          Zhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
          Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
          Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          Synonyms10-Hydroxycamptothecin, HCPT
          DescriptionA cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.
          FormPale yellow powder
          CAS number64439-81-2
          Chemical formulaC₂₀H₁₆N₂O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
          Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
          Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.