208722 | Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

208722
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₆N₂O₄ 88191-84-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208722-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
          Catalogue Number208722
          Brand Family Calbiochem®
          SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
          References
          ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
          Rami, A., et al. 1997. Neurosci. Res. 27, 93.
          Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Chard, P.S., et al. 1995. Neuroscience 65, 1099.
          Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
          Product Information
          CAS number88191-84-8
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₂₂H₂₆N₂O₄
          Chemical formulaC₂₂H₂₆N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
          Biological Information
          Primary Targetcalpain 1, calpain 2
          Primary Target IC<sub>50</sub>8 nM
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Val-Phe-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208722

          References

          Reference overview
          Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
          Rami, A., et al. 1997. Neurosci. Res. 27, 93.
          Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Chard, P.S., et al. 1995. Neuroscience 65, 1099.
          Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure

          Citations

          Title
        • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
        • Dong, Y., et al. 2006. FASEB Journal in press,.
        • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
        • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
          DescriptionA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
          FormWhite lyophilized solid
          CAS number88191-84-8
          Chemical formulaC₂₂H₂₆N₂O₄
          Peptide SequenceZ-Val-Phe-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml). Use only anhydrous DMSO.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
          Rami, A., et al. 1997. Neurosci. Res. 27, 93.
          Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Chard, P.S., et al. 1995. Neuroscience 65, 1099.
          Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
          Citation
        • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
        • Dong, Y., et al. 2006. FASEB Journal in press,.
        • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
        • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors